Oncolytic Effect of Viruses in Tissue Cultures.

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Abstract
Tumor implants, growing in roller tube cultures, demonstrated a marked oncolytic response to St. Louis encephalitis infection. Two human and 2 rodent tumors were destroyed completely by this virus. Infections with Lansing poliomyelitis, Newcastle disease, herpes and chick embryo-adapted influenza A viruses did not interfere with growth of tissue implants. Rabies virus appeared to stimulate the growth of such tumor implants. The tissue culture technic can be used as a survey tool in rapidly determining the cytopathogenic effect of viral agents on tumors.