Cell Cycle Phase Sensitivity to Cis‐Dichloro‐Bis (Isopropylamine) Trans‐Dihydroxy Platinum (Iv) (Chip)

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Abstract
Cis‐dichloro‐bis (isopropylamine) trans‐dihydroxy platinum (IV) (CHIP) is a second generation platinum coordination complex now in Phase II clinical trials. In vitro studies with Chinese Hamster Ovary cell cultures show that CHIP is a phase‐sensitive drug, being most cytotoxic to cells in early G1 phase and least toxic to late S and G1 phase cells. the dose‐modifying factor between the drug sensitivity of cells treated in G1 and in late S phase is 1.6. These findings and their clinical significance are discussed with respect to the phase sensitivity of other cytotoxic agents.