Increased I131 Collection by the Thyroid of the Rat in Acute Starvation
- 31 January 1953
- journal article
- research article
- Published by American Physiological Society in American Journal of Physiology-Legacy Content
- Vol. 172 (2) , 291-294
- https://doi.org/10.1152/ajplegacy.1953.172.2.291
Abstract
An increased collection of radioactive iodine without structural change (mean acinar cell height) of the thyroid gland was observed in rats that were starved for 24 hrs. after receiving a tracer dose of I131. The uptake of I131 and the mean acinar cell height is somewhat lower in normally fed Long-Evans rats than in Wistar rats, but the uptake after 24-hr. starvation was increased in both strains. Oral administration of 10 [mu]g. of I to the fasted animals restored the uptake of I131 to the level observed on normal feeding. The caloric replacement of diet with pure glucose without iodine did. not decrease the elevated I131 uptake observed on fasting. Fasted animals force fed with large amts. of water showed an increased I131 uptake. All these results seem to indicate that the increased I131 uptake without structural change of the thyroid gland,observed in animals fasted for 24 hrs. after receiving the tracer dose,is due to acute dietary iodine deficiency.Keywords
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