Variations in Rabbit Aortic Endothelial and Medial Histamine Synthesis in Pre- and Early Experimental Atherosclerosis

Publisher Website
Google Scholar
Abstract
The histamine-forming capacity (HFC) of aortic endothelium and medial tissue was examined in rabbits fed 0.5% cholesterol for 2- and 4-wk periods, thereby producing both a pre-atherosclerotic and histologically identifiable early stage of atherosclerosis. With respect to the HFC of endothelium isolated from aortas of control animals, that of cells isolated from aortas following the 2-wk feeding period is essentially double, while no difference exists between the HFC of aortic endothelium from control animals and that of the 4-wk dietary group. The medial HFC is similar in all groups. One pre-atherosclerotic metabolic change is apparently an increase in the capacity of endothelial cells to form histamine, and such a process may occupy a role in increased aortic permeability, an essential component of the atherogenic process.

This publication has 2 references indexed in Scilit: