Role of endogenous interferon in the anti‐tumor effect of poly I·C and statolon as demonstrated by the use of anti‐mouse interferon serum

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Abstract
We have determined the effect of sheep anti-mouse interferon globulin on the anti-tumor effects of poly I·C, statolon, tilorone, pyran copolymer and BCG in mice inoculated with Ehrlich ascites or L 1210 lymphoma cells. Whereas the anti-tumor effects of poly I·C and statolon were nullified when mice were injected with immunoglobulins, the anti-tumor effects of pyran copolymer and BCG were not modified by this treatment. We conclude that interferon mediates the anti-tumor activity of poly I·C and statolon in these experimental systems. It is suggested that anti-interferon serum provides a direct method of determining whether other biologic effects attributed to viruses, poly I·C, statolon, tilorone, pyran copolymer (and possibly other interferon inducers) are mediated or not by interferon.