Preserved myocardial [123I]metaiodobenzylguanidine uptake in autosomal recessive juvenile parkinsonism: First case report
- 9 February 2005
- journal article
- case report
- Published by Wiley in Movement Disorders
- Vol. 20 (5) , 634-636
- https://doi.org/10.1002/mds.20384
Abstract
A decrease in myocardial uptake of iodine‐123–labeled metaiodobenzylguanidine (123I‐MIBG) has been reported in idiopathic Parkinson's disease (PD) using 123I‐MIBG myocardial scintigraphy. However, the patient with autosomal recessive juvenile parkinsonism (AR‐JP), caused by the parkin gene, presented here showed normal 123I‐MIBG myocardial uptake, suggesting that AR‐JP is a distinct disease entity from PD. Although the clinical features of AR‐JP are sometimes quite similar to those of late‐onset idiopathic PD, 123I‐MIBG myocardial scintigraphy may be a powerful tool to differentiate PD from other parkinsonian syndromes, including AR‐JP. © 2005 Movement Disorder SocietyKeywords
This publication has 12 references indexed in Scilit:
- Diagnostic considerations in juvenile parkinsonismMovement Disorders, 2003
- Pseudo-autosomal dominant inheritance of PARK2: two families with parkin gene mutationsJournal of the Neurological Sciences, 2003
- Sympathetic cardiac denervation in Parkinson's disease and pure autonomic failure but not in multiple system atrophyJournal of Neurology, Neurosurgery & Psychiatry, 2002
- Peripheral sympathetic dysfunction in patients with Parkinson's disease without autonomic failure is heart selective and disease specificEuropean Journal of Nuclear Medicine and Molecular Imaging, 2000
- Differentiation of Parkinson’s disease and multiple system atrophy in early disease stages by means of I-123-MIBG–SPECTJournal of the Neurological Sciences, 2000
- Cardiac uptake of [ 123 I]MIBG separates Parkinson’s disease from multiple system atrophyNeurology, 1999
- 123I-metaiodobenzylguanidine myocardial scintigraphy in Parkinson's diseaseJournal of Neurology, Neurosurgery & Psychiatry, 1999
- Mutations in the parkin gene cause autosomal recessive juvenile parkinsonismNature, 1998
- Neuropathology of Autonomic Nervous System in Parkinson's DiseaseEuropean Neurology, 1997
- Familial juvenile parkinsonismNeurology, 1994