Effects of Methylxanthines on Adenosine 3',5'–Monophosphate and Corticosterone in the Rat Adrenal

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Abstract
The possibility that phosphodiesterase inhibitors might potentiate the adrenal stimulating action of ACTH was investigated using a new agent, l–methyl,3–isobutylxanthine. This agent was approximately ten times as potent as theophylline in inhibiting the enzymatic hydrolysis of cyclic AMP by phosphodiesterase activity found in the 1000 X g supernate of rat adrenal homogenates. At a concentration of 1 HIM, it increased cyclic AMP concentrations and corticosterone production by quartered rat adrenals in the absence of ACTH. Appropriate doses of 1–methyl, 3–isobutylxanthine were shown to potentiate the effects of ACTH with respect to adrenal cyclic AMP concentrations and corticosterone production, both in vitro and in vivo, in the rat. (Endocrinology92: 525, 1973)

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