Rat strain differences in copulatory behavior after para-chlorophenylalanine and hormone treatment.

Publisher Website
Google Scholar
Abstract
The potentiation of masculine copulatory behavior in castrated male rats following systemic p-chlorophenylalanine (PCPA), a tryptophan hydroxylase inhibitor, treatment depended upon the strain of rat and the recency of castration. Wistar (W) and Sprague-Dawley (SD) males displayed a decline in behavioral responsiveness to PCPA treatment following castration, the W males retaining their behavioral responsiveness longer than SD males. Castrated W males were behaviorally more responsive to androgen replacement than were SD males. Ovariectomized W and SD females receiving estrogen replacement displayed a strain difference in hormonal sensitivity. In tests for feminine copulatory behavior, ovariectomized W females were behaviorally more sensitive to estrogen treatment than SD females. Ovariectomized and estrogen-primed females of both strains displayed potentiated lordotic behavior following chronic PCPA treatment. Concomitant treatment with dexamethasone to reduce adrenal steroid output abolished the potentiation of lordotic behavior found with PCPA treatment.