RATE OF ABSORPTION OF ESTERS OF OESTRONE AND OESTRADIOL AS DETERMINED BY FEATHER TESTS

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Abstract
The well-known response of the breast feathers of the Brown Leghorn capon to oestrogens can readily be used to determine the rate of absorption of different esters [Parkes, 1937]. In the male the breast feathers are black; injection of oestrogen while feathers are growing causes deposition of the fawn pigment characteristic of the female. Only that part of the feather is changed which is growing when oestrogen is present; existing plumage is not affected. Since the rate of feather growth is known, the width of the fawn bar in the black feather indicates the time during which effective amounts of oestrogen were circulating. Thus, if a single injection is given, the duration of effect of a compound can easily be ascertained. In the work previously recorded the duration of action of the following substances was examined: oestrone, oestrone acetate, oestrone benzoate, oestrone methyl ether, oestradiol, oestradiol diacetate, oestradiol monobenzoate, oestradiol

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