Interaction of Cobalt and Iron in Riboflavine Production of Candida guilliermondii.

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Abstract
The effect of Co on the production of riboflavin by C. guilliermondii was studied. The yeast was grown in a continuous culture with Fe as the growthlimiting factor. When the Fe concentration of the nutrient medium was small enough (0.5 [mu]g/liter) Co had no effect. At higher Fe concentrations Co stimulated the riboflavin production and the highest riboflavin production was obtained at an Fe concentration of 5 [mu]g/liter and a Co concentration of 15-25 mg/liter. It was concluded that Co specifically replaces Fe at the site where Fe is necessary for the binding of riboflavin in the cell. Thus Co competes with Fe and produces the same effect as Fe deficiency.

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