Evidence of Genetic Heterogeneity of Some Lentogenic Newcastle Disease Virus Strains

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Abstract
Two distinguishable subpopulations were recovered from chickens infected with lentogenic strains of Newcastle disease virus originally isolated from chickens in Australia and Ireland. In both instances, a subpopulation that rapidly eluted from chicken erythrocytes was recovered predominantly from tracheal swabs, and a slow-eluting subpopulation from cloacal swabs. The 2 subpopulations differed in thermostability of the hemagglutinin, mean survival time of infected chicken embryos and in elution pattern. The heterogeneity characteristic of the Aust-V4 strain and NI-Ulster strain could not be demonstrated in B1, NJ-LaSota and ENG-F lentogenic strains commonly used in vaccines. The question is discussed of whether standard vaccine strains are also heterogeneous and the significance of possible heterogeneity to the effectiveness of the vaccines.

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