NICOTINE INFLUENCE UPON THE DEVELOPMENT OF EXPERIMENTAL STOMACH TUMORS

  • 1 January 1982
    • journal article
    • research article
    • Vol. 52  (4) , 259-265
Abstract
The study of nicotine action upon N-methyl-N''-nitro-N-nitrosoguanidine (MNNG) stomach cancer development was carried out in rats. Combined MNNG and nicotine introductions long-term led to stomach pretumorous changes of the whole mucous membrane, earlier development of stomach cancer tumors and doubled frequency over controls and progressive decrease of acetylcholinesterase activity, especially in homogenates of cerebral hemispheres, the hypothalamic region and medulla oblongata (where this activity practically failed to be expressed). Nicotine evidently has the ability to enhance MNNG-stomach carcinogenesis in rats. The possible action of the autonomic nervous system in such nicotine effects is under discussion.