Reaction Optimization Using Solid-Phase Catalysis-CD HTS: Nb-Imidazoline−Cu(I)-Catalyzed Asymmetric Benzoylation of 1,2-Diols
- 22 February 2007
- journal article
- letter
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 9 (6) , 1145-1147
- https://doi.org/10.1021/ol0702122
Abstract
Catalytic asymmetric benzoylation of 1,2-diols has been developed using a solid-phase asymmetric catalyst. The reaction conditions were optimized by the screening of different metal salts, solvents, bases, and temperatures. High-throughput screening was performed using circular dichroism detection, and the results revealed that Nb-imidazoline-copper(I) in combination with diisopropylethylamine was able to catalyze with high enantioselectivity, giving the monobenzoylated products in high yields and excellent enantiomeric excesses of up to 95% ee. [reaction: see text]Keywords
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