PROLONGATION OF HETEROTOPIC HEART ALLOGRAFT SURVIVAL IN RATS BY USE OF ANTIGEN-ANTIBODY COMPLEXES

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Abstract
Treatment of BN [rat] recipients with soluble WAG/Rij histocompatibility antigens (HCA) did not produce prolongation of (WAG/Rij .times. BN)F1 heart allografts, but resulted in specific sensitization of the recipients in most cases. Three different anti-WAG/Rij sera (ADS) were tested, alone or complexed in equivalence to 0.5 mg of HCA. Depending on the serum used, ADS alone produced only a moderate prolongation of heart allograft survival or had no effect at all. Antigen-antibody complexes given i.v. on days 0, 2, 4, 6 and 8 induced a prolonged or indefinite cardiac graft survival (> 200 days), as well as accelerated graft rejection, depending on the source of the ADS used in immune complex formation. One month after heart transplantation, BN recipients, treated with antigen-antibody complexes, demonstrated normal graft-vs.-host reactivity of peripheral blood lymphocytes, but rejected donor-type skin grafts in a slightly delayed fashion.

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