Linkage but Not Association of Calpain-10 to Type 2 Diabetes Replicated in Northern Sweden
Open Access
- 1 June 2006
- journal article
- Published by American Diabetes Association in Diabetes
- Vol. 55 (6) , 1879-1883
- https://doi.org/10.2337/db05-1495
Abstract
We present data from a genome-wide scan identifying genetic factors conferring susceptibility to type 2 diabetes. The linkage analysis was based on 59 families from northern Sweden, consisting of a total of 129 cases of type 2 diabetes and 19 individuals with impaired glucose tolerance. Model-free linkage analysis revealed a maximum multipoint logarithm of odds score of 3.19 for D2S2987 at 267.7 cM (P = 0.00058), suggesting that a gene conferring susceptibility to type 2 diabetes in the northern Swedish population resides in the 2q37 region. These data replicate, in a European population, previously identified linkage of marker loci in this region to type 2 diabetes in Mexican Americans. In contrast, no evidence in support of association to the previously identified single nucleotide polymorphisms in the calpain-10 gene was observed in a case-control cohort derived from the same population.Keywords
This publication has 27 references indexed in Scilit:
- Genome-wide linkage analysis of type 2 diabetes mellitus reconfirms the susceptibility locus on 11p13–p12 in JapaneseJournal of Human Genetics, 2004
- Haploview: analysis and visualization of LD and haplotype mapsBioinformatics, 2004
- Are Variants in the CAPN10 Gene Related to Risk of Type 2 Diabetes? A Quantitative Assessment of Population and Family-Based Association StudiesAmerican Journal of Human Genetics, 2004
- The CTLA4 region as a general autoimmunity factor: An extended pedigree provides evidence for synergy with the HLA locus in the etiology of type 1 diabetes mellitus, Hashimoto's thyroiditis and Graves' diseaseEuropean Journal of Human Genetics, 2003
- Merlin—rapid analysis of dense genetic maps using sparse gene flow treesNature Genetics, 2001
- Studies of Association between the Gene for Calpain-10 and Type 2 Diabetes Mellitus in the United KingdomAmerican Journal of Human Genetics, 2001
- The Finland–United States Investigation of Non–Insulin‐Dependent Diabetes Mellitus Genetics (FUSION) Study. II. An Autosomal Genome Scan for Diabetes‐Related Quantitative‐Trait LociAmerican Journal of Human Genetics, 2000
- Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitusNature Genetics, 2000
- ErratumAmerican Journal of Human Genetics, 2000
- Mapping of a gene for type 2 diabetes associated with an insulin secretion defect by a genome scan in Finnish familiesNature Genetics, 1996