An In-vitro Model of Malignant Hyperthermia
Open Access
- 1 April 1978
- journal article
- research article
- Published by Wolters Kluwer Health in Anesthesiology
- Vol. 48 (4) , 254-259
- https://doi.org/10.1097/00000542-197804000-00006
Abstract
Clinical concentrations of anesthetics augment caffeine-induced contracture of frog sartorius muscle; anesthetics differ in this characteristic. The potentiation was quantitated using 6 paired sartorius muscles for each specified concentration of anesthetic and controls. At a concentration of 1 MAC [minimum anesthetic concentration], the greatest potentiation occurred with 2 mM caffeine for all anesthetics studied. Under these conditions the order of magnitude of augmentations was: chloroform (15 .times.); halothane (11 .times.); methoxyflurane (10 .times.); cyclopropane (5 .times.); enflurane (4 .times.); isoflurane (3 .times.); diethyl ether (2 .times.); Baxter 3224 (2 .times.); fluroxene (1.4 .times.); nitrous oxide (1.3 .times.). Halothane at .5 MAC augmented the 2 mM caffeine-induced contracture almost 7 .times., and at 2 MAC almost 13 .times.; 2 MAC isoflurane potentiated the caffeine-induced contracture only 4 .times. and 4 MAC diethyl ether only 2.5 .times.. It is postulated that those anesthetics that most potentiate caffeine-induced contracture may be the most potent triggering agents of malignant hyperthermia.This publication has 1 reference indexed in Scilit: