Demethylchlortetracycline

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Abstract
IN August, 1957, McCormick et al.1 described a new family of compounds closely related to the previously known tetracyclines. Two of them, 6demethyltetracycline (DMT) and 7-chloro-6-demethylchlortetracycline (DMCT), were produced by a mutant of the strain of Streptomyces aureofaciens Duggar, from which chlortetracycline was originally produced. These new antibiotics were found to be highly resistant to degradation by acid and alkali and to have about the same activity as the corresponding 6-methylated analogues. Preliminary studies by Sweeney and Hardy2 indicated that oral administration of DMCT to human subjects yielded more sustained levels of antibiotic in the blood than either tetracycline or . . .

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