A statistical analysis of clinical records of patients suffering from pemphigus has been undertaken by few authors. Although most authors agree that pemphigus is a serious disease, it is believed by some that it is usually fatal while others hold to the belief that a reasonable number of patients survive. In order to obtain more complete information about the course of the disease, follow-up studies were carried out on all patients with pemphigus admitted to the Massachusetts General Hospital between the years 1921 and 1936. Of the 63 patients with pemphigus who had come under observation during this period, follow-up data were obtained on all except 1. In this communication the records of the 62 patients who were followed are reviewed. The period was closed in 1936 so that an adequate length of time would have elapsed after the onset of symptoms for observation of the clinical course. Only those