Molecular aspects of calcified tissue

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Abstract
The detailed relation between primary, secondary, tertiary, and ultrastructure of collagen is presented. Electron micrographs of stained collagen are described in terms of specific peptide location. Data relating to the interaction of polysaccharides, notably chondroitin‐6‐sulfate, and proteoglycan and collagen are reviewed and a model for connective tissue developed. The relationship between such structure and that of calcified tissue is examined and some new data pertaining to the mechanism of calcification are introduced.