Cytopathogenic Effect of Newcastle Virus in Monkey Kidney Cultures and Interference with Poliomyelitis Viruses.

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Abstract
Newcastle disease virus accidentally encountered in chicken plasma used as a tissue culture reagent was serially propagated in monkey kidney epithelial cells with the production of granular degeneration and disintegration. Ten to 50% of these cells escaped the cytopathogenic effect of the virus and were then found to be almost completely resistant to the cytopathogenic effect of the 3 types of poliomyelitis and Type 3 human "enteric" viruses; partial resistance as evidenced by a delay in appearance of cytopathogenic change was demonstrated for Types 1,2, and 5 human "enteric" viruses.

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