Catalytic Asymmetric Claisen Rearrangement in Natural Product Synthesis: Synthetic Studies toward (−)-Xeniolide F

Abstract
The catalytic asymmetric Claisen rearrangement (CAC) of a highly substituted and functionalized α-alkoxycarbonyl-substituted allyl vinyl ether has been exploited to gain access to an advanced building block for the projected total synthesis of (−)-xeniolide F, the enantiomer of a xenicane diterpene isolated from a coral of the genus Xenia.