ASSOCIATION OF LUNG FUNCTION WITH ATHEROSCLEROTIC RISK FACTORS AMONG JAPANESE AMERICANS: SEATTLE NIKKEI HEALTH STUDY

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Abstract
1. Impaired lung function has been reported to be associated with mortality from all causes, cardiovascular disease (CVD) and aortic pulse wave velocity (PWV). The aim of the present study was to examine the association between impaired lung function and atherosclerotic risk factors, including PWV, blood pressure, lipids, smoking and alcohol intake, among Japanese Americans. 2. The study subjects were 678 adult Japanese Americans who participated in CVD screening conducted under the Seattle Nikkei Health Study. Subjects with abnormal lung function were defined as those with forced vital capacity (FVC%) < 80% of predicted or forced expiratory volume in 1 s (FEV1%) < 80% of predicted. We conducted logistic regression analyses by using abnormal lung function as dependent variables. 3. The significant predictors positively associated with abnormal FVC% were age (60 years or older) and hypertension. Being a current drinker or an ex-drinker was independently and negatively associated with abnormal FVC%. The significant predictors positively associated with abnormal FEV1% were age (60 years or older), sex (male), hypertension and being a current smoker. Being a current drinker was independently and negatively associated with abnormal FEV1%. 4. In conclusion, the present study does not support the previously reported association of abnormal lung function with PWV. However, our findings imply that light and moderate drinking may be a protective factor of lung function and that hypertension and smoking may impair lung function.