Cancer Induction in Hamsters by Human Type 12 Adenovirus. Effect of Route of Injection.

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Abstract
Summary Tumors were induced at the site of injection of human type 12 adenovirus into newborn hamsters by each of the intrapulmonary, intrapleural, intraperitoneal, intravenous and subcutaneous routes, leading to death within 29 to 108 days. Whereas at higher doses of virus the subcutaneous route of injection was as effective as the other routes, at lower doses of virus it appeared less effective. For the intracranial route of injection, no local tumors were observed but one such hamster developed multiple abdominal tumors, and 3 developed hydrocephalus. Of 35 hamsters with tumors at the site of injection by various routes, remote tumors in the liver also developed in 10. Similar liver tumors were also found in 4 intravenously injected hamsters without a tumor at the site of intravenous injection. Of 7 hamsters administered virus by intranasal instillation, none have died of tumors in approximately 9 months to date.

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