Estimation of Radiation Dose-Reduction Factor for β-Mercaptoethylamine by Endogenous Spleen Colony Counts

Publisher Website
Google Scholar
Abstract
A radiation dose-reduction factor (DRF) for the protective agent [beta]-mer-captoethylamine is estimated from counts of the colonies grossly visible on the spleen 10 days after irradiation. A logarithmic transformation would be appropriate but is precluded by the existence of zero counts. A modification is described which yields values regressing linearly with dose, the lines for control and treated groups having a common intercept at zero dose. The DRF estimated as the ratio of these slopes, 1.6 (1.5 to 1.7), is in agreement with the DRF values obtained with other response metameters. The value of the intercept, 3.4 (3.0 to 3.8) x 104 colony-forming units/spleen, agrees with the number obtained by direct experimentation.

This publication has 0 references indexed in Scilit: