EFFECTS OF LOPERAMIDE ON THE MOTILITY OF THE ISOLATED INTESTINE IN GUINEA PIGS, RATS AND DOGS.
- 1 January 1977
- journal article
- abstracts
- Published by Japan Society of Smooth Muscle Research in Japanese Journal of Smooth Muscle Research
- Vol. 13 (2) , 69-74
- https://doi.org/10.1540/jsmr1965.13.69
Abstract
Effects of Loperamide on the motility of the isolated intestine in guinea-pigs, puppies and rats were examined. The spontaneous contractions of the small intestine and colon in puppies were inhibited at relatively high concentration of the agent (10(-5) g/ml). The peristaltic reflex in the guinea-pig ileum was slightly inhibited at concentrations of 10(-8) to 10(-7) g/ml, and was completely abolished at 10(-6) g/ml. The agent (2X10(-7) g/ml) inhibited the longitudinal contraction of the guinea-pig ileum elicited by transmural electric stimulation. The agent (10(-5) g/ml) inhibited the acetylcholine-induced contraction of the colon and small intestine in puppies, and induced the hyperpolarization of the membrane potential and the abolition of spike potentials of the intestinal muscle in rats.Keywords
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