Oral Cholecystographic Agents and the Thyroid
Open Access
- 1 May 2001
- journal article
- other
- Published by The Endocrine Society in Journal of Clinical Endocrinology & Metabolism
- Vol. 86 (5) , 1853-1860
- https://doi.org/10.1210/jc.86.5.1853
Abstract
Oral cholecystographic agents (OCAs) are known to affect thyroid hormone metabolism by acting as potent inhibitors of type I and type II deiodinases, blocking the conversion of T4 to T3 and rT3 to T2. In addition, iodine released from the drug blocks thyroid gland secretion of thyroid hormone. These properties make OCAs a potentially useful drug therapy in patients with hyperthyroidism and other thyrotoxic disorders. Short-term treatment with OCAs rapidly reduces serum T3 levels, with a lesser effect on T4 levels. OCAs are not useful for long-term treatment, which is usually followed by exacerbation of hyperthyroidism with continued use. The lack of significant side effects makes these drugs an excellent short-term option in situations where a rapid clinical improvement is critical.Keywords
This publication has 0 references indexed in Scilit: