Mitochondria in the diabetic heart
Open Access
- 16 July 2010
- journal article
- review article
- Published by Oxford University Press (OUP) in Cardiovascular Research
- Vol. 88 (2) , 229-240
- https://doi.org/10.1093/cvr/cvq239
Abstract
Diabetes mellitus increases the risk of developing cardiovascular diseases such as coronary artery disease and heart failure. Studies have shown that the heart failure risk is increased in diabetic patients even after adjusting for coronary artery disease and hypertension. Although the cause of this increased heart failure risk is multifactorial, increasing evidence suggests that derangements in cardiac energy metabolism play an important role. In particular, abnormalities in cardiomyocyte mitochondrial energetics appear to contribute substantially to the development of cardiac dysfunction in diabetes. This review will summarize these abnormalities in mitochondrial function and discuss potential underlying mechanisms.Keywords
This publication has 136 references indexed in Scilit:
- Substrate-Specific Derangements in Mitochondrial Metabolism and Redox Balance in the Atrium of the Type 2 Diabetic Human HeartJournal of the American College of Cardiology, 2009
- Contribution of Impaired Myocardial Insulin Signaling to Mitochondrial Dysfunction and Oxidative Stress in the HeartCirculation, 2009
- Diabetic cardiomyopathy-associated dysfunction in spatially distinct mitochondrial subpopulationsAmerican Journal of Physiology-Heart and Circulatory Physiology, 2009
- Increased Enzymatic O-GlcNAcylation of Mitochondrial Proteins Impairs Mitochondrial Function in Cardiac Myocytes Exposed to High GlucoseJournal of Biological Chemistry, 2009
- Conditional increase in SERCA2a protein is able to reverse contractile dysfunction and abnormal calcium flux in established diabetic cardiomyopathyAmerican Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2008
- Mitochondrial fission mediates high glucose-induced cell death through elevated production of reactive oxygen speciesCardiovascular Research, 2008
- Autophagy in the Pathogenesis of DiseaseCell, 2008
- Alterations in the diabetic myocardial proteome coupled with increased myocardial oxidative stress underlies diabetic cardiomyopathyPublished by Elsevier ,2007
- Role of adiponectin in human skeletal muscle bioenergeticsCell Metabolism, 2006
- Superoxide activates mitochondrial uncoupling proteinsNature, 2002