IMMUNOPEROXIDASE DEMONSTRATION OF A NEW MUSCLE PROTEIN (Z-PROTEIN) IN MYOGENIC TUMORS AS A DIAGNOSTIC-AID

  • 1 January 1984
    • journal article
    • research article
    • Vol. 114  (1) , 164-170
Abstract
Z-protein, a new muscle protein with a MW of 55,000 daltons, is an excellent marker for muscle differentiation in paraffin sections. Positive staining by a peroxidase-antiperoxidase technique for detection of intracellular Z-protein was observed in 2 of 2 cardiac rhabdomyomas, 5 of 5 leiomyomas, 9 of 10 leiomyosarcomas, and in 15 of 18 rhabdomyosarcomas including 5 of 5 of the pleomorphic type, 7 of 9 of the embryonal type and 3 of 4 of the alveolar type. Other types of tumors (77 cases) that sometimes mimic myogenic tumors on histologic examination gave negative results. The immunoperoxidase method for detection of intracellular Z-protein is of use in distinguishing myogenic tumors from other types of tumors.