TRANSPLANTATION IMMUNITY, IMMUNOLOGICAL TOLERANCE, AND CHICKEN × TURKEY INTERSPECIFIC HYBRIDS

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Abstract
Evidence is presented that adult turkey X chicken interspecific hybrids promptly reject tissue grafts from donors of both parental species and from other turkey-chicken hybrids. In addition, whole blood from these animals inoculated onto the chorioallantoic membranes of chick embryos consistently produces a high degree of splenomegaly. These findings indicate that the capacity of hybrids to react against the normal transplantation isoantigens of the parental species is fully developed. The results are discussed in relation to the apparent lack of specificity of immunological tolerance of tissue grafts alleged to occur following interspecific embryonic parabiosis.