Analysis of Cell-free Epstein-Barr Virus-associated RNA in the Plasma of Patients with Nasopharyngeal Carcinoma
- 1 August 1999
- journal article
- research article
- Published by Oxford University Press (OUP) in Clinical Chemistry
- Vol. 45 (8) , 1292-1294
- https://doi.org/10.1093/clinchem/45.8.1292
Abstract
Chen et al. (1) and Nawroz et al. (2) have reported that tumor-derived DNA is detectable in the plasma and serum of cancer patients and have opened up a new molecular approach for the early detection of malignancy. It is not known, however, whether circulating tumor-derived RNA is also present in plasma, because of the lability of RNA. To address this possibility, we used nasopharyngeal carcinoma (NPC) as a model system and attempted to detect Epstein-Barr virus (EBV)-latent gene transcripts in cell-free plasma samples from NPC patients.Keywords
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