Experience with a slow-release formulation of oxprenolol.

  • 12 April 1978
    • journal article
    • research article
    • Vol. 87  (609) , 245-6
Abstract
Fifteen hypertensive patients with well controlled blood pressure on antihypertensive regiments consisting of a diuretic (in all but one) and a thrice-daily regimen of oxprenolol, were switched to an equal total daily dose of slow-release oxprenolol given once daily. Other drugs were continued unchanged. Observations on blood pressure and heart rate during half-day tests (lying, standing and post-exercise) indicated a little loss of control of the blood pressure towards the end of the 24-hour period when the next daily dose was due. Ectopic beats associated with exertion were observed more frequently at the end of the 24-hour period. Maximum advantage would seem to be gained by giving slow-release oxprenolol as a twice daily regimen with two-thirds of the daily dose in the morning and one-third at night.

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