EFFECTS OF A COMBINED STOMACHIC AND ITS INGREDIENTS ON RABBIT STOMACH MOTILITY IN SITU

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Abstract
The combined stomachic contained cinnamon [Cinnamomum cassia], fennel [Foeniculum vulgare], orange peel [Citrus nobilis], nutmeg [Myristica fragrans], gentian [Gentiana lutea], quassia [Picrasma ailanthoides], clove [Eugenia caryophyllata], sodium bicarbonate, synthetic aluminum silicate, precipitated calcium carbonate, magnesium carbonate, biotamylase and 1-menthol. The combined stomachic (130-650 mg/kg orally) accelerated the spontaneous movement of the unanesthetized rabbit stomach dose-dependently. To obtain a clear response, 1300 mg/kg of the combined stomachic was used. The combined stomachic reduced the inhibition of stomach movement by sodium pentobarbitone. A similar stimulating effect was obtained with fennel, gentian, 1-menthol or a mixture of the crude drugs but not with a mixture of antacids, cinnamon, clove, nutmeg or quassia. The stimulating effect of the combined stomachic on stomach movement was abolished by atropine sulfate (2.0 mg/kg i.v.) or hexamethonium bromide (2.0 mg/kg, i.v.). Stomach movement depressed by sodium pentabarbitone was stimulated by the combined stomachic, whose effective ingredients were fennel, gentian and 1-menthol. Their action appears to be due to an increase in cholinergic nerve activity but not to direct stimulation of the smooth muscle itself.

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