In Vitro Effect of Cyclophosphamide Metabolites on Chromosomes of Fanconi Anaemia Patients
- 1 August 1980
- journal article
- research article
- Published by Wiley in British Journal of Haematology
- Vol. 45 (4) , 565-568
- https://doi.org/10.1111/j.1365-2141.1980.tb07179.x
Abstract
Summary The effect of cyclophosphamide metabolites was studied on chromosomes of Fanconi anaemia patients, parents and controls. A high susceptibility of FA patients chromosomes was observed when low concentrations of sera of a cyclophosphamide-treated patient was added to PHA-stimulated lymphocyte cultures. No effect was observed with comparable concentrations on cells from FA patients or controls. The high susceptibility of FA cells is discussed in relation to the high sensitivity of FA patients to cyclophosphamide when used as a conditioning drug for bone marrow graft.This publication has 14 references indexed in Scilit:
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