Smooth muscle of rabbit aorta contains ?1- but not ?2-Adrenoceptors

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Abstract
We have investigated the residual contractile response to noradrenaline remaining after phenoxybenzamine (3×10−7 mol/l) in rabbit aorta, since it has been reported that phenoxybenzamine at low doses completely and irreversibly blocks α1- but not α2-adrenoceptors. The contraction elicited by noradrenaline slowly recovered with time after it had been almost abolished by phenoxybenzamine. This residual response was blocked by the α1-selective antagonist prazosin (3×10−8 mol/l) but not by the α2-selective antagonist rauwolscine (3×10−7 mol/l). The results confirm that the smooth muscle of rabbit aorta contains α1- not α2-adrenoceptors.