Sarin Poisoning in Guinea Pigs Compared to Reactivation of Acetylcholinesterase in Vitro as a Basis for Therapy
- 13 March 2009
- journal article
- research article
- Published by Wiley in Acta Pharmacologica et Toxicologica
- Vol. 55 (1) , 1-5
- https://doi.org/10.1111/j.1600-0773.1984.tb01954.x
Abstract
Contrary to the large number of publications dealing with treatment of organophosphate poisoning in a variety of animal species, there is no logical reason in the preference of 1 spp., for this purpose. Guinea pigs were reported to respond better to treatment by oximes than mice and rats. In the analysis of data on the effect of obidoxim and atropine or benactyzine on sarin poisoning it was demonstrated that guinea pigs did not respond differently from mice and rats. S.c. LD50 of sarin in mice ranged from 0.06-0.207 mg/kg, and those of guinea pigs from 0.04-0.112 mg/kg. The difference in the LD50 may have been related to the different susceptibility of various animal species. The importance of in vivo dosage, mode of application, kinetics of antagonists, in correlation to the ability to reactivate in vitro was discussed.Keywords
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