The role of protein kinase C in cell surface signal transduction and tumour promotion
- 1 April 1984
- journal article
- review article
- Published by Springer Nature in Nature
- Vol. 308 (5961) , 693-698
- https://doi.org/10.1038/308693a0
Abstract
Protein kinase C has a crucial role in signal transduction for a variety of biologically active substances which activate cellular functions and proliferation. When cells are stimulated, protein kinase C is transiently activated by diacylglycerol which is produced in the membrane during the signal-induced turnover of inositol phospholipids. Tumour-promoting phorbol esters, when intercalated into the cell membrane, may substitute for diacylglycerol and permanently activate protein kinase C. The enzyme probably serves as a receptor for the tumour promoters. Further exploration of the roles of this enzyme may provide clues for understanding the mechanism of cell growth and differentiation.Keywords
This publication has 66 references indexed in Scilit:
- Calcium, phospholipid turnover and transmembrane signallingPhilosophical Transactions of the Royal Society of London. B, Biological Sciences, 1983
- Phospholipid degradation and signal translation for protein phosphorylationTrends in Biochemical Sciences, 1983
- Calcium and Phospholipid Turnover as Transmembrane Signaling for Protein PhosphorylationPublished by Elsevier ,1982
- The stimulation of inositol lipid metabolism that accompanies calcium mobilization in stimulated cells: defined characteristics and unanswered questionsPhilosophical Transactions of the Royal Society of London. B, Biological Sciences, 1981
- Phosphatidyldmositol hydrolysis: A multifunctional transducing mechanismMolecular and Cellular Endocrinology, 1981
- Calcium-dependent protein kinase: widespread occurrence in various tissues and phyla of the animal kingdom and comparison of effects of phospholipid, calmodulin, and trifluoperazine.Proceedings of the National Academy of Sciences, 1980
- Three Multifunctional Protein Kinase Systems in Transmembrane ControlPublished by Springer Nature ,1980
- Unsaturated diacylglycerol as a possible messenger for the activation of calcium-activated, phospholipid-dependent protein kinase systemBiochemical and Biophysical Research Communications, 1979
- Phosphorylation-Dephosphorylation of EnzymesAnnual Review of Biochemistry, 1979
- Inositol phospholipids and cell surface receptor functionBiochimica et Biophysica Acta (BBA) - Reviews on Biomembranes, 1975