Nerve impulse blockage in squid axons by n‐alkanes: the effect of axon diameter.
- 1 December 1982
- journal article
- research article
- Published by Wiley in The Journal of Physiology
- Vol. 333 (1) , 393-403
- https://doi.org/10.1113/jphysiol.1982.sp014460
Abstract
The anesthetic effects of aqueous solutions of the n-alkanes pentane to nonane on the propagated action potential of squid axons were investigated for a range of axon diameters. The mechanisms which may underly the increased sensitivity of small axons to impulse blockade by n-alkanes are discussed. A quantitative comparison is made between the effects of n-hexane, n-heptane and n-octane on the action potential. This supports the idea of a real decline in anesthetic potency on ascending the homologous series, rather than an effect due to long diffusion times and solution depletion.This publication has 13 references indexed in Scilit:
- Some effects of n‐pentane on the sodium and potassium currents of the squid giant axon.The Journal of Physiology, 1981
- Some effects of aliphatic hydrocarbons on the electrical capacity and ionic currents of the squid giant axon membrane.The Journal of Physiology, 1980
- An anatomical basis for the resistance and capacitance in series with the excitable membrane of the squid giant axonJournal of Neurocytology, 1977
- The molecular mechanisms of anaesthesiaNature, 1977
- CONDUCTION-BLOCKING CONCENTRATIONS OF ANESTHETICS INCREASE WITH NERVE AXON DIAMETER - STUDIES WITH ALCOHOL, LIDOCAINE AND TETRODOTOXIN ON SINGLE MYELINATED FIBERS1977
- The rate of action of tetrodotoxin on sodium conductance in the squid giant axonPhilosophical Transactions of the Royal Society of London. B, Biological Sciences, 1975
- Predicted amplitude and form of action potentials recorded from unmyelinated nerve fibresJournal of Theoretical Biology, 1971
- Substrate specificity at the alkane binding sites of hemoglobin and myoglobinBiochemistry, 1969
- The susceptibility of nerve fibres to analgesicsAnaesthesia, 1963
- Local anesthetics. An electrophysiological investigation of local anesthesia of peripheral nerves, with special reference to xylocaine.1961