Synthesis and Evaluation of a Broad Range of New Chiral (Aminoalkyl)phosphane Ligands for Asymmetric Hydrogen‐Transfer Reduction of Prochiral Ketones
- 16 September 2003
- journal article
- research article
- Published by Wiley in European Journal of Organic Chemistry
- Vol. 2003 (19) , 3761-3768
- https://doi.org/10.1002/ejoc.200300131
Abstract
Twenty new chiral (aminoalkyl)phosphane ligands have been prepared from four enantiomerically pure advanced chiral compounds. We describe their use for asymmetric hydrogen‐transfer reduction of three prochiral ketones. Enantioselectivities up to 90% were obtained. We investigated the influence on the enantioselectivity of each part of these new (aminoalkyl)phosphane ligands. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003)Keywords
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