One-Pot Preparation of Chiral .BETA.-Amino Esters by Rhodium-Catalyzed Three-Components Coupling Reaction.
- 1 January 2002
- journal article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 50 (2) , 307-308
- https://doi.org/10.1248/cpb.50.307
Abstract
Chiral beta-amino esters are synthesized in one-pot from three components, amines, aldehydes, and ethyl bromoacetate, under the rhodium-catalyzed Reformatsky-type reaction condition, where complete diastereoselection is achieved in the nucleophilic addition step of ethyl bromoacetate to the imines prepared inKeywords
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