Iminium ion-mediated cyclizations of 4-aryl-1,4-dihydropyridines. Alternate cyclization pathways
- 1 March 1986
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Chemistry
- Vol. 64 (3) , 556-559
- https://doi.org/10.1139/v86-089
Abstract
Acid-catalyzed cyclization of dimethyl 2,6-dimethyl-4-[(2-ethenyl-5-methoxy)phenyl]-1,4-dihydropyridine-3,5-dicarboxy-late affords novel products via competing intramolecular processes. The present mechanistic pathways differ from previous iminium ion-mediated cycloadditions, to afford conformationally constrained dihydropyridine analogs for study as calcium antagonists. These results illustrate the ability of the dihydropyridine nucleus to function as either a nucleophile or an electrophile, depending upon substituents in the aryl ring.This publication has 4 references indexed in Scilit:
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