Technetium Tc 99m-Macroaggregated Albumin Angiography and Perfusion

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Abstract
INTRA-ARTERIAL chemotherapy offers an alternative to systemic (intravenous) chemotherapy for localized neoplasms. Infusion of chemotherapeutic agents directly into the arterial supply of a neoplasm allows higher local tissue concentrations without a corresponding increase in systemic toxic reactions.1 Intra-arterial chemotherapy is generally infused at a slow rate (about 40 mL/hr); therefore, a method of assessing perfusion at this slow rate is needed. Conventional angiography under fluoroscopic guidance does not allow for adequate visualization at slow flow rates. We are reporting on the use of technetium Tc 99m-macroaggregated albumin (MAA), infused through intra-arterial catheters at slow flow rates that approximate the chemotherapy infusion rate, in 843 examinations for assessment of regional perfusion. TECHNIQUE FOR TECHNETIUM Tc 99m-MAA STUDY Placement of Arterial Catheter An arterial catheter, introduced either via the femoral or brachial artery, is positioned to lie with its tip in the artery supplying the neoplasm to which chemotherapy is to

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