Isolation of New Protein Phosphatase Inhibitors from Two Cyanobacteria Species, Planktothrix spp.
- 1 August 2001
- journal article
- review article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 64 (8) , 1052-1055
- https://doi.org/10.1021/np0005356
Abstract
Two new protein phosphatase inhibitors, oscillamide B (1) and C (2), were isolated from the cyanobacteria Planktothrix (Oscillatoria) agardhii and P. rubescens. The structures of the inhibitors were elucidated by analysis of HRFABMS, 1D and 2D NMR spectra, and chemical degradation. These inhibitors are ureido-containing cyclic peptides and inhibited serine/threonine protein phosphatases PP1 and PP2A. The inhibitory activities were closely related to the Arg and N-Me-Hty residues in the peptides.Keywords
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