Synthesis of Alkynyl Ketones via Palladium- and Copper-Catalyzed Carbonylative Cross Coupling of Iodonium Salts with Alk-1-ynes
- 1 August 1997
- journal article
- research article
- Published by Georg Thieme Verlag KG in Synthesis
- Vol. 1997 (08) , 874-876
- https://doi.org/10.1055/s-1997-1285
Abstract
The palladium- and copper-catalyzed coupling of iodonium salts with alk-1-ynes in the presence of atmospheric pressure of carbon monoxide in DME/H2O (4:1) and Pd(OAc)2 (0.2 mol%) [or Pd(OAc)2 with CuI (10 mol%) and NaHCO3 (1.2 equiv)], or CuI (10 mol%) and NaHCO3 (2.2. equiv) at 30°C afforded α,β-acetylenic ketones.Keywords
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