De novo Acute Myelogenous Leukemia with Trilineage Myelodysplasia Associated with t(8;21)(q22;q22).
- 1 January 1999
- journal article
- case report
- Published by Japanese Society of Internal Medicine in Internal Medicine
- Vol. 38 (7) , 607-611
- https://doi.org/10.2169/internalmedicine.38.607
Abstract
We describe a rare case of de novo acute myelogenous leukemia with trilineage myelodysplasia (AML/TMDS) associated with t(8;21)(q22;q22). The patient was admitted to our hospital with leukocytopenia. AML/TMDS was diagnosed by excess myeloblasts and morphological findings of bone marrow. The karyotype revealed 45, X, -Y, t(8;21)(q22;q22) in 17 of 20 analyzed mitoses, and also AML1/MTG8 transcripts were detected by the reverse transcription polymerase chain reaction (RT-PCR) method. The patient achieved a complete remission with a combination chemotherapy of daunorubicin, cytarabine, and prednisolone. This case suggests that t(8;21)(q22;q22) may participate in the pathogenesis of AML/TMDS, although this type is usually found as one of the chromosomal abnormalities in de novo acute myelogenous leukemia (AML) with maturation.Keywords
This publication has 0 references indexed in Scilit: