Effect of X-Irradiation upon the Infective Larvae of Ancylostoma caninum and the Immunogenic Effect in Dogs of a Single Infection with 40 kr-Irradiated Larvae

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Abstract
X-irradiation of the infective larvae of Ancylostoma caninum reduces the infectivity of the larvae as measured by subsequent intestinal establishment of adult hookworms. As the dose of radiation is increased the infectivity of the larvae is decreased and the pathogenicity to the host of the resulting burden of hookworms is reduced. Male larvae are more sensitive to the effects of X-irradiation than are female larvae, particularly at the higher levels of irradiation. At radiation doses of 40 kr and greater the female worms in the resulting population are invariably sterile. A single subcutaneous vaccination of dogs aged 3 months with 1,000 40 kr-irradiated larvae confers a highly significant resistance. This vaccination confers highly satisfactory resistance to the pathogenic effects of such a challenge, when measured in terms of hematological, clinical, and coprological changes.

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