THE CONTROL OF LEISHMANIASES

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  • 1 January 1980
    • journal article
    • research article
    • Vol. 58  (6) , 807-818
Abstract
Human leishmaniases are caused by at least 13 different species and subspecies [L. donovani donovani, L. d. infantum, L. d. chagasi, L. tropica, L. major, L. aethiopica, L. braziliensis guyanensis, L. b. panamensis, L. mexicana mexicana, L. m. amazonensis, L. m. pifanoi, L. peruviana, L. garnhami] of parasite of Leishmania. These parasites are transmitted to man from other infected persons or mammals by sandflies when taking a blood meal. Leishmaniases have been reported from about 80 countries and probably some 400,000 new cases occur each year. Clinically the leishmaniases can be divided into 3 major groups: visceral leishmaniases, which are usually fatal if untreated; cutaneous leishmaniases, which often produce permanent facial disfigurement; and mucocutaneous leishmaniasis of the New World, which produces severe mutilation by destruction of the naso-oro-pharyngeal cavity and somtimes death. Since the various forms of leishmaniasis differ substantially from each other in their epidemiology, the stategy for control must be adapted to the local situation in each endemic area, after thorough ecological and epidemiological studies of the vectors, host and the landscape. If insufficient baseline information is available, failure of haphazardly applied control measures can be expected. Peridomestic insecticide spraying together with treatment of patients is effective in certain foci of anthroponotic cutaneous leishmaniasis, urban visceral leishmaniasis and uta. Extensive programs to eradicate desert rodents, combined with land reclamation, resulted in a considerable decrease in the incidence of zoonotic cutaneous leishmaniasis in vast areas of the USSR. Since control of zoonotic cutaneous/mucocutaneous leishmaniasis of the New World is hardly feasible at present, the only rational approach to prevent some of the mucosal lesions is early diagnosis and radical treatment of patients with the rather unsatisfactory drugs presently available.

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