Antipsychotic drugs: is more worse? a meta-analysis of the published randomized control trials
- 1 May 1994
- journal article
- research article
- Published by Cambridge University Press (CUP) in Psychological Medicine
- Vol. 24 (2) , 307-316
- https://doi.org/10.1017/s003329170002729x
Abstract
Synopsis: Effectiveness and side-effects of high- versus low-dose neuroleptic treatment of chronic psychosis have been assessed through a meta-analysis of 22 published randomized control trials comparing different neuroleptic doses. No incremental clinical improvement was found at doses above 375 mg equivalent of chlorpromazine, while a significant increase in adverse reactions was observed.Keywords
This publication has 42 references indexed in Scilit:
- Publication Bias and Dissemination of Clinical ResearchJNCI Journal of the National Cancer Institute, 1989
- Dose of Fluphenazine, Familial Expressed Emotion, and Outcome in SchizophreniaArchives of General Psychiatry, 1988
- Prescribing for the Long-term Mentally IllThe British Journal of Psychiatry, 1988
- Treatment-resistant Schizophrenia: Controlled Study of Moderate- and High-dose ThiothixeneInternational Clinical Psychopharmacology, 1987
- Findings for Public Health From Meta-AnalysesAnnual Review of Public Health, 1985
- Dissimilar dosing with high-potency and low-potency neurolepticsAmerican Journal of Psychiatry, 1984
- Low-Dose Neuroleptic Treatment of Outpatient SchizophrenicsArchives of General Psychiatry, 1983
- What is the best maintenance dose of neuroleptics in schizophrenia?Psychiatry Research, 1980
- Drug and Family Therapy in the Aftercare of Acute SchizophrenicsArchives of General Psychiatry, 1978
- Very High Dose Fluphenazine DecanoateArchives of General Psychiatry, 1976