Studies on Kidney Function in Subjects Exposed to Organic Solvents

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Abstract
The renal concentrating ability was studied in 11 subjects by means of 14–16 hours of fluid deprivation, alone and in combination with the vasopressin analogue desmopressin. The effect of desmopressin without fluid deprivation on urinary osmolality was also studied. The combination of desmopressin and fluid deprivation was not superior to fluid deprivation alone for the production of concentrated urine. Desmopressin alone was inferior to the other two methods. No difference in renal concentrating ability could be demonstrated after 14 hours of fluid deprivation, when comparing 118 subjects exposed to various organic solvents with 48 controls.