Dopamine And The Kidney
- 4 June 2019
- book chapter
- Published by Taylor & Francis
Abstract
It has been known for nearly 50 years that dopamine (DA) has an unusual profile of cardiovascular activity when compared with the other catecholamines, noradrenaline (NA) and adrenaline. The earliest demonstrations of this came from the laboratory of Holtz, who showed that in guinea pigs and rabbits, DA, unlike adrenaline or noradrenaline, was depressor. 1 Although various suggestions were made along the lines that this unusual activity was related to the formation of vasodilator metabolites, the depressor response can be seen with hindsight to have been due at least mainly to intrarenal effects of the DA molecule itself. These early experiments with DA have been reviewed fully by Goldberg, 2 and are not further described here.This publication has 1 reference indexed in Scilit:
- Die enzymatische Entstehung von Oxytyramin im Organismus und die physiologische Bedeutung der DopadecarboxylaseNaunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie, 1942