Alloantigen-Activated CML Suppression Independent of Cytotoxic Activity

Open Access
Publisher Website
Google Scholar
Abstract
The generation of T cell-mediated lympholysis (CML) in murine mixed lymphocyte cultures (MLC) can be impeded if allogeneic responding and stimulating cells are incubated in the presence of lymphocytes that have been activated by prior exposure to alloantigens (1–6). The mechanism by which alloantigen-activated cells reduce levels of cytotoxic activity generated in fresh MLC remains to be determined. Several independent investigators have suggested that CML-suppressive cells are actually alloantigen-activated cytotoxic T cells (2, 4). These cells would diminish normal CML responses by eliminating MLC stimulator cells and, thus, the cell-borne signals required for CML generation. Other investigators, attempting to rule out this possibility, have relied on indirect arguments to support their contention (3, 6, 7). We herein report the generation and detection of potent CML suppressive activity under conditions in which cytotoxicity has been eliminated as a possible mechanism of suppression. Materials and Methods. Mice.

This publication has 0 references indexed in Scilit: